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发布于:2018-6-22 10:50:07  访问:1 次 回复:0 篇
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The Down-side Danger Of the MDV3100 Who Nobody Is Posting About
We selected cisplatin-based Con-RT plus adjuvant PF chemotherapy and a PF-based sequential chemoradiotherapy as the reference arms. Con-RT + PF: cisplatin-based concurrent chemoradiotherapy plus adjuvant PF chemotherapy; GEM: gemcitabine; NPC: nasopharyngeal carcinoma; PF: cisplatin�Cfluorouracil regimen; sGC-RT: sequential chemoradiotherapy with cisplatin�Cgemcitabine regimen; sPF-RT, sequential chemoradiotherapy with cisplatin�Cfluorouracil regimen Between August 2006 and July 2007, a total of 240 patients with newly diagnosed, biopsy-proven, nonmetastatic Stages III�CIVA-B NPC, according to the AJCC 6th Edition Criteria, were eligible for enrollment into this MDV3100 mouse randomized study. All the patients were treated at the Cancer Center, buy AZD6244 Sun Yat-Sen University, South China. Additional eligibility criteria included a Karnofsky performance status of at least 80; adequate renal function as demonstrated by a creatinine clearance rate of at least 60 mL/min; a WBC ��3.5 �� 109 L?1; a platelet count ��100 �� 109 L?1 and a hemoglobin level ��100 g/L. Exclusion criteria included the following: the presence of distant metastases; age ��60 years or <16 years; pregnancy or lactating; a history of renal disease; unstable cardiac disease requiring treatment and a history of previous RT in the nasopharyngeal region or a history of previous chemotherapy. The study was performed with approval from the institutional Ethics Committee, and each patient provided written informed consent prior to any study-specific procedure. The cohort composed of 183 males and 57 female patients, with a male to female ratio of 3.2 to 1. The median age was 44.4 years (range, 16�C60 years). Histologically, all patients had Type II or Type III disease, according to the World Health Organization (WHO) criteria. All patients completed a pretreatment evaluation that included a full medical history, physical examination, hematology and biochemistry profiles, MRI of the neck and nasopharynx, CT of chest and abdomen, abdominal ultrasonography and a whole body bone scan using single-photon emission computed tomography. Patients were randomly assigned into one of three I-BET151 treatment arms (Fig. 1). The randomization codes were produced using a computerized random number generator. Participant characteristics (including age, gender, T classification, N classification and stage groups) were well balanced between the groups in this trial (Table 1). All patients were treated with definitive intent radiation therapy using a two-phase technique. Details of the RT technique used at the Cancer Center of Sun Yat-Sen University have been previously reported.14 All patients were treated using 6 MV linear accelerators (Varian, Palo Alto, CA) and conventional fractionation (2 Gy per fraction).
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